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This chapter does not present a compendium of information on toxicology or adverse effects of specific agents.

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One important part of this task is the identification of the organ first or most affected by a toxic agent; this organ is defined as the target organ.In modern society, toxicology has become an important element in environmental and occupational health.This is because many organizations, governmental and non-governmental, utilize information from toxicology to evaluate and regulate hazards in the workplace and nonoccupational environment.These are: genetic determinants, or inherited susceptibility/resistance factors; and age, sex and other factors such as diet or co-existence of infectious disease.

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These factors can also affect exposure and dose, through modifying uptake, absorption, distribution and metabolism.The second factors, of metabolism, relate to understanding how the body handles absorbed substances.